Amine/Maleimide PEG reagent, 4-Mal-methyl-cyclohexanecarboxamide-methyl-[1,2,3]triazole-PEG8-amine, Purity 98%

Synonym: BP-23733; 4-Mal-methyl-cyclohexanecarboxamide-methyl-[1,2,3]triazole-PEG8-amine

PubChem CID: 155569759

Size

100 mg; 250 mg; 500 mg; 1 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

4-Mal-methyl-cyclohexanecarboxamide-methyl-[1,2,3]triazole-PEG8-amine is a PEG linker that combines several functional groups, including a maleimide group, a methyl-cyclohexanecarboxamide, a triazole unit, and an amine group. The maleimide group is reactive with thiol groups, allowing for covalent bonding to thiol-containing biomolecules. The triazole group is typically formed via a click chemistry reaction, enabling efficient conjugation with azide-functionalized molecules. The hydrophilic PEG spacer (8 ethylene glycol units) enhances solubility in aqueous environments, making the compound suitable for a variety of research applications. The amine group allows further derivatization and conjugation with other reactive functional groups.

Molecular Weight

712.8

Molecular Formula

C₃₃H₅₆N₆O₁₁

Functional Group 1

Amine

Functional Group 2

Maleimide

Reactive Group 1

Acid

Reactive Group 2

Thiol

Reactive Group 3

Nucleophile

Form

Oil

Purity

98%

Solubility

Water, DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

4-Mal-methyl-cyclohexanecarboxamide-methyl-[1,2,3]triazole-PEG8-amine is ideal for use in creating bioconjugates, particularly in applications requiring efficient thiol- and azide-based crosslinking, such as drug delivery systems, antibody-drug conjugates (ADCs), and biomolecular complex formation. The maleimide group facilitates the coupling of proteins or peptides with thiol-containing compounds, while the triazole unit enables biorthogonal click chemistry for conjugation with azide-labeled targets. This compound is useful in targeted therapy, biomolecule labeling, and the development of multifunctional molecular tools for molecular biology research.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.