Amine/NHS PEG reagent, t-Boc-N-amido-PEG1-NHS ester, Purity 98%

Synonym: 1260092-55-4; t-Boc-N-amido-PEG1-NHS ester; Boc-N-PEG1-C₂-NHS ester; 2,5-Dioxopyrrolidin-1-yl 3-(2-((tert-butoxycarbonyl)amino)ethoxy)propanoate; BocNH-PEG1-CH₂CH₂COONHS

CAS Number: 1260092-55-4
PubChem CID: 59422090

Size

250 mg; 500 mg; 1 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

t-Boc-N-amido-PEG1-NHS ester functions as a PEG linker featuring both an NHS ester and Boc-protected amino groups. The hydrophilic nature of its PEG spacer enhances solubility in aqueous solutions, while the Boc group can be removed under mild acidic conditions to produce free aminogroups suitable for additional conjugations involving primary amines t-from proteins or modified oligonucleotides.

Molecular Weight

330.3

Molecular Formula

C₁₄H₂₂N₂O₇

Functional Group 1

Boc

Functional Group 2

Amine

Functional Group 3

NHS

Reactive Group 1

Acid

Reactive Group 2

Amine

Form

Solid or viscous liquid

Purity

98%

Identity

Confirmed by NMR.

Applications

t-Boc-N-amido-PEG1-NHS ester is frequently employed in peptide synthesis and modification. The t-Boc protecting group is useful for controlling the reaction sequence and protecting specific amino groups during synthesis. The PEG moiety can improve the solubility and stability of the peptides. It can be used to prepare peptide conjugates for targeted drug delivery, where the PEG chain helps in evading the immune system and increasing the circulation time.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.