Amine/SPDP PEG reagent, SPDP-PEG-amine, MW 2,000, Purity 95%

Synonym: Amine/SPDP PEG reagent; SPDP-PEG-amine

Size

100 mg; 250 mg; 500 mg; 1 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SPDP-PEG-amine is a reagent grade pyridyl disulfide modified polyPEG which reacts with thiol moiety to produce a new disulfide bond and generate unreactive pyridine-2-thione as a by-product. The newly formed disulfide bond is cleaved with a reducing agent such as DTT. The amine moiety is reactive with an activated ester (NHS) or with a carboxylic acid in the presence of an activator, such as HATU or EDC.

Molecular Weight

2,000

Functional Group 1

Amine

Functional Group 2

SPDP

Functional Group 3

None

Reactive Group 1

Acid

Reactive Group 2

NHS

Reactive Group 3

Thiol

Form

Solid

Purity

95%

Identity

Confirmed by NMR.

Applications

SPDP-PEG-amine is employed in attaching various biomolecules, providing a route to create stable bioconjugates that are useful in drug delivery systems. The newly-formed disulfide bond is cleaved with a reducing agent such as dithiothreitol (DTT).

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.