Amino/Bromide PEG reagent, N-Boc-PEG4-bromide, Purity 98%

Synonym: 1392499-32-9; N-Boc-PEG4-bromide; N-Boc-PEG5-bromide; BocNH-PEG4-CH₂CH₂Br

MDL: MFCD31536756
CAS Number: 1392499-32-9
PubChem CID: 88853548

Size

100 mg; 250 mg; 500 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

N-Boc-PEG4-bromide is a PEG linker compound featuring a tert-butoxycarbonyl (Boc)-protected amino group and a bromide group. The incorporation of the Boc protecting group shields the amino functionality, providing stability during synthetic processes. Under mild acidic conditions, the Boc group can be selectively removed, yielding the free amine for further chemical reactions. The presence of the bromide (Br) moiety imparts reactivity to the molecule, serving as an excellent leaving group for nucleophilic substitution reactions. Moreover, the hydrophilic nature of the PEG spacer enhances the solubility of N-Boc-PEG4-bromide in aqueous environments, facilitating its use in aqueous-based reactions and biological applications.

Molecular Weight

400.3

Molecular Formula

C₁₅H₃₀BrNO₆

Functional Group 1

Amino

Functional Group 2

Bromide

Functional Group 3

None

Form

Liquid

Purity

98%

Solubility

DCM

Identity

Confirmed by NMR.

Applications

N-Boc-PEG4-bromide can be used as a versatile building block in organic synthesis and chemical conjugation strategies. The Boc protecting group ensures the controlled deprotection of the amino functionality, enabling precise manipulation of the PEG linker. Upon deprotection, the resulting free amine can undergo various conjugation reactions or participate in bioconjugation processes. The bromide group enhances the synthetic flexibility of N-Boc-PEG4-bromide, allowing for the introduction of diverse functional groups or biomolecules onto the PEG backbone via- nucleophilic substitution reactions.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.