Description
Bromoacetamido-PEG2-AZD is a PEG linker comprising an AZD (azido) group and a bromide group, known for its excellent leaving ability in nucleophilic substitution reactions. With a hydrophilic PEG spacer, this linker demonstrates enhanced solubility in aqueous environments, facilitating its use in diverse biological and chemical applications.
Applications
Bromoacetamido-PEG2-AZD is widely employed in bioconjugation chemistry for the modification of biomolecules and the synthesis of conjugates. The AZD group enables click chemistry reactions with alkynes, facilitating the conjugation of Bromoacetamido-PEG2-AZD to various molecules, including proteins, peptides, and nucleic acids. Moreover, the bromide group serves as an effective leaving group, ensuring efficient substitution reactions with nucleophiles.