Description
AZD-PEG5-methyl ester is a PEG linker comprising an AZD (azido) group and a methyl ester group. The methyl ester functionality can undergo hydrolysis under strong basic conditions, leading to the cleavage of the ester bond.
Applications
AZD-PEG5-methyl ester can be employed in various bioconjugation reactions, particularly in the context of click chemistry, where the AZD group reacts with alkynes or strained cyclooctynes. After conjugation, the methyl ester can be selectively cleaved under strong basic conditions, allowing for controlled release of the attached payload or modification of the conjugated molecule.