Description
17-(Azide-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester serves as a PEG linker that contains both an azide group and a t-butyl ester functionality. The azide can participate in copper-catalyzed click chemistry reactions involving alkynes, DBCO, and BCN to yield triazole structures. Moreover, the t-butyl protected carboxylic acid can be deprotected under acidic conditions.
Applications
This compound can be used in the field of lipid modification and the synthesis of lipid-based nanoparticles for drug delivery. The PEG moiety enhances the solubility and biocompatibility of the lipid molecules. The azide group enables conjugation with other molecules for targeted delivery or functionalization.