Description
5-(Azido-PEG4)-pent-2-yn-1-ol acts as a PEG linker incorporating both an azide group and a terminal hydroxyl group. The hydrophilic nature of the PEG spacer enhances solubility in water-based solutions. The azide functionality can engage in reactions with alkyne compounds, BCN, and DBCO through click chemistry techniques to yield stable triazole linkages. Furthermore, the hydroxyl group allows for additional derivatization or substitution with other reactive functional groups.
Applications
5-(Azido-PEG4)-pent-2-yn-1-ol can be employed in the modification of biomolecules to introduce reactive sites for further conjugation. In the field of surface functionalization, it can be used to attach biomolecules or nanoparticles onto surfaces for biosensors or tissue engineering.