Description
Azido-PEG4-oxazolidin-2-one is a bifunctional crosslinker that features both an azide group and an oxazolidin moiety. The presence of the azide allows for click chemistry applications. Additionally, the oxazolidin-2-one group serves as an effective ligand for copper-catalyzed N-arylation reactions involving pyrrole, imidazole, and indole. The hydrophilic PEG spacer enhances solubility in aqueous solutions.
Applications
In the field of polymer science, it can be incorporated into polymeric materials to introduce specific functionalities and modify their physical and chemical properties. In drug delivery systems, it could be used to attach drugs or therapeutic agents, allowing for controlled release and targeted delivery. It can also be employed in the synthesis of peptide-based therapeutics to enhance their stability and bioavailability. In the area of surface modification, it can be used to functionalize surfaces of nanoparticles or biomaterials to improve their biocompatibility and interaction with biological systems.