Description
Azido-PEG8-t-Boc-hydrazide serves as a monodisperse PEG reagent featuring an azide group and a Boc-protected hydrazide. The hydrophilic PEG spacer improves solubility in water-based media. The azide functionality can engage in reactions with alkynes, BCN, and DBCO via click chemistry techniques to yield stable triazole linkages. Furthermore, the Boc protecting group can be removed under mild acidic conditions to generate a reactive hydrazide that may couple with various carbonyl groups.