Azide/Carboxylic acid PEG reagent, Azido-PEG4-CH2CO2H, Purity 98%

Azide/Carboxylic acid PEG reagent, Azido-PEG4-CH₂CO₂H, Purity 98%

Synonym: 201467-81-4; Azido-PEG4-CH₂CO₂H; N₃-PEG4-CH₂COOH; N33-TEG-COOH; 14-azido-3,6,9,12-tetraoxatetradecanoic acid

CAS Number: 201467-81-4

PubChem CID: 10516636

Size

100 mg; 500 mg; 1 g; 5 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Azido-PEG4-CH₂CO₂H represents a widely used linker featuring an azide group along with a terminal carboxylic acid functionality suitable for click chemistry applications. The hydrophilic PEG spacer increases solubility in aqueous media while allowing the azide moiety to react with alkyne compounds like BCN or DBCO through click chemistry methods to create stable triazole linkages. Moreover, the terminal carboxylic acid can interact with primary amines when activated by agents such as EDC or HATU.

Molecular Weight

277.3

Molecular Formula

C₁₀H₁₉N₃O₆

Functional Group 1

Acid

Functional Group 2

Azide

Functional Group 3

None

Reactive Group 1

Amine

Reactive Group 2

Alkyne

Form

Solid

Purity

98%

Identity

Confirmed by NMR.

Applications

In the field of drug delivery, it can be used to modify the surface of nanoparticles or liposomes to enhance their biocompatibility and circulation time in the bloodstream. It can also be employed to attach drugs to carrier molecules for targeted delivery to specific tissues or cells. In the area of biomaterials, it can be incorporated into scaffolds for tissue engineering to improve cell adhesion and proliferation. Additionally, it can be utilized in the modification of proteins or peptides to regulate their activity and stability.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.

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