Description
Azido-PEG5-CH2CO2-PFP serves as a PEG linker incorporating both an azide and a PFP group, separated by one carbon atom between the PEG arm and the PFP ester. The azide moiety can participate in copper-catalyzed click chemistry reactions with alkynes. Additionally, the PFP group reacts with amines to create stable bonds and exhibits lower susceptibility to hydrolysis. The hydrophilic nature of the PEG spacer enhances solubility in aqueous solutions, while longer PEG chains further improve these solubility characteristics.
Applications
Azido-PEG5-CH2CO2-PFP can be used in the modification of proteins, antibodies, or peptides to create bioconjugates for therapeutic or diagnostic purposes. It can also be applied in the development of biosensors or in the synthesis of biomaterials with tailored properties.