Azide/DOTA PEG reagent, DOTA-(t-Butyl)3-PEG5-azide, Purity 95%

Synonym: DOTA-tris(t-Bu)ester-PEG5-C₂-azide; tert-butyl 2-[4-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethyl]-7,10-bis[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetate

Size

10 mg; 25 mg; 50 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

DOTA-(t-Butyl)3-PEG5-azide contains both DOTA-(t-butyl) and azide functionalities. The DOTA-(t-butyl) component exhibits solubility in DMF and DCM solvents. Under acidic conditions, the t-butyl groups can be removed to generate free carboxylic acids. Moreover, the azide moiety is frequently utilized in copper-catalyzed click chemistry reactions involving alkynes such as DBCO and BCN.

Molecular Weight

861.1

Molecular Formula

C₄₀H₇₆N₈O₁₂

Functional Group 1

Azide

Functional Group 2

DOTA

Functional Group 3

None

Reactive Group 1

Alkynyl

Form

Solid

Purity

95%

Identity

Confirmed by NMR.

Applications

This compound is particularly valuable in the field of medical imaging and targeted therapy. The DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) moiety can chelate various metal ions, such as gadolinium for magnetic resonance imaging (MRI) or radioactive isotopes for positron emission tomography (PET) imaging.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.