Azide/NHS PEG reagent, Azido-PEG8-NHS ester, Purity 98%

Synonym: 1204834-00-3; Azido-PEG8-NHS ester; 1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid succinimidyl ester; N₃-PEG8-CH₂CH₂COONHS ester; 2,5-DIOXOPYRROLIDIN-1-YL 1-AZIDO-3,6,9,12,15,18,21,24-OCTAOXAHEPTACOSAN-27-OATE

CAS Number: 1204834-00-3
PubChem CID: 51340932

Size

100 mg; 500 mg; 1 g; 5 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Azido-PEG8-NHS ester is a widely used reagent for click chemistrythat features both an azide and an NHS ester functionality. Its hydrophilic PEG spacer increases solubility in aqueous environments. As previously noted, its azide moiety can react with alkyne compounds like BCN or DBCO through click chemistry processes leading to stable triazole formations. Additionally, the NHS ester allows labeling of primary amines t-present in proteins and other amine-containing entities.

Molecular Weight

564.6

Molecular Formula

C₂₃H₄₀N₄O₁₂

Functional Group 1

Azide

Functional Group 2

NHS

Functional Group 3

None

Reactive Group 1

Alkynyl

Reactive Group 2

Amine

Form

Solid

Purity

98%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

This compound is often used for the modification of biomolecules, especially proteins. The NHS ester group reacts with amine groups on proteins, and the long PEG chain improves the solubility and stability of the modified biomolecules. It can also be used in the preparation of drug delivery systems or surface modification of materials.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.