Azide/NHS/Carboxylic acid PEG reagent, Azido-PEG1-CH₂CO₂-NHS, Purity 98%

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Cat. No.: X24-09-YYX475

Azide/NHS/Carboxylic acid PEG reagent, Azido-PEG1-CH₂CO₂-NHS, Purity 98%

Synonym: 1480545-09-2; 2,5-dioxopyrrolidin-1-yl 2-(2-azidoethoxy)acetate; (2,5-dioxopyrrolidin-1-yl) 2-(2-azidoethoxy)acetate

CAS Number: 1480545-09-2
PubChem CID: 121235812

Size

100 mg; 250 mg; 500 mg; 1 g

Price

Datasheet

MSDS

Properties

Description

Azido-PEG1-CH₂CO₂-NHS acts as a PEG linker containing both azide and NHS ester functionalities. The hydrophilic PEG spacer improves water solubility in aqueous solutions. The azide group can engage in reactions with alkynes, BCN, and DBCO via click chemistry methods to yield stable triazole linkages. Moreover, the NHS ester allows for labeling primary amines t-found in proteins, amine-modified oligonucleotides, and other molecules containing amines.

Molecular Weight

242.2

Molecular Formula

C₈H₁₀N₄O₅

Functional Group 1

NHS

Functional Group 2

Azide

Functional Group 3

Acid

Reactive Group 1

Alkyne

Reactive Group 2

Amine

Form

Solid

Purity

98%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

In the area of protein modification, it can be employed to attach PEG chains to proteins, altering their pharmacokinetic and immunogenic properties. It is useful in the preparation of antibody-drug conjugates for targeted cancer therapy. In the field of biolabeling and imaging, it can be used to tag biomolecules for detection and visualization. Moreover, it can contribute to the fabrication of microfluidic devices with functionalized surfaces for biological assays.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.

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