Azide/Val-Cit dipeptide/PAB PEG reagent, Azido-PEG1-Val-Cit-PAB-OH, Purity 98%

Synonym: 2055041-40-0; N₃-PEG1-Val-Cit-PAB-OH; Azido-PEG1-Val-Cit-PAB-OH; Azide-PEG1-Val-Cit-PABC-OH; DTXSID101110100

CAS Number: 2055041-40-0
PubChem CID: 119058240

Size

50 mg; 100 mg; 250 mg; 500 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Azido-PEG1-Val-Cit-PAB-OH is an advanced ADC (Antibody-Drug Conjugate) linker featuring a cleavable design. The Val-Cit sequence is selectively cleaved by the lysosomal enzyme Cathepsin B, ensuring targeted release of the attached payload within the cell. The presence of the azido group facilitates efficient conjugation with DBCO, BCN, or other alkyne-functionalized molecules via- click chemistry. Moreover, the inclusion of a PEG spacer enhances the aqueous solubility of the linker, facilitating its use in various biological applications.

Molecular Weight

520.6

Molecular Formula

C₂₃H₃₆N₈O₆

Functional Group 1

Azide

Functional Group 2

Val-Cit dipeptide

Functional Group 3

PAB

Reactive Group 1

PNP

Form

Solid

Purity

98%

Identity

Confirmed by NMR.

Applications

Azido-PEG1-Val-Cit-PAB-OH in the development of ADCs for targeted cancer therapy. By leveraging the specificity of Cathepsin B, the ADC payload is released exclusively within the lysosomes of cancer cells, thereby maximizing therapeutic efficacy while minimizing off-target effects. The compatibility with click chemistry enables facile conjugation of the linker to various drug molecules or biomolecules, allowing for precise customization and optimization of ADCs for specific therapeutic applications.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.