BCN PEG reagent, Endo-BCN-NHS carbonate, Purity 98%

Synonym: 1426827-79-3; Rel-((1R,8S,9R)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (2,5-dioxopyrrolidin-1-yl) carbonate; (1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl succinimidyl carbonate; Rel-(1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethyl (2,5-dioxopyrrolidin-1-yl) carbonate

CAS Number: 1426827-79-3
PubChem CID: 75412386

Size

25 mg; 50 mg; 100 mg; 250 mg

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Endo-BCN-NHS carbonate is a succinimidyl ester/NHS functionalized cyclooctyne derivative, (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl succinimidyl carbonate. It enables the addition of the cyclooctyne moiety into amine-containing compounds or biomolecules. The BCN group reacts with azide-tagged biomolecules under copper-free conditions.

Molecular Weight

291.3

Molecular Formula

C₁₅H₁₇NO₅

Functional Group 1

BCN

Functional Group 2

None

Functional Group 3

None

Reactive Group 1

Azide

Form

Solid

Purity

98%

Identity

Confirmed by NMR.

Applications

Endo-BCN-NHS carbonate is indispensable in bioconjugation chemistry, facilitating specific coupling reactions with azide-tagged biomolecules. Its use in copper-free click chemistry allows for efficient labeling and modification of proteins, peptides, and other biomolecules for various research and diagnostic applications, including imaging, drug delivery, and biomaterials development.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.