Cat. No.: X24-03-YW0022
BCN/NHS PEG reagent, Endo-BCN-PEG8-NHS ester, Purity 98%
Synonym: 1608140-48-2; Endo-BCN-PEG8-NHS ester; Endo-bcn-peg8-nhsester; (2,5-Dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-[2-[[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methoxycarbonylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate; SCHEMBL24801713
- CAS Number: 1608140-48-2
- PubChem CID: 146013013
Properties
Description
Endo-BCN-PEG8-NHS ester is a monodisperse PEG linker featuring an NHS ester group and a BCN group. It labels primary amines (-NH2) in proteins, amine-modified oligonucleotides, and other amine-containing molecules. The BCN group enables reaction with azide-tagged biomolecules under copper-free conditions. The hydrophilic PEG spacer enhances solubility in aqueous media.
Molecular Formula
C34H54N2O14
Solubility
DMSO, DCM, DMF
Identity
Confirmed by NMR.
Applications
Endo-BCN-PEG8-NHS ester is crucial in bioconjugation, allowing specific labeling of primary amines. Its NHS ester functionality ensures efficient conjugation under mild conditions. The BCN group broadens its utility, facilitating coupling reactions with azide-tagged biomolecules. The hydrophilic PEG spacer improves compatibility with aqueous environments, making it suitable for various applications such as protein labeling, drug delivery, and biomaterials development.
For Research Use Only. Not For
Clinical Use.