Benzyl/Tos PEG reagent, Benzyl-PEG2-Tos, Purity 98%

Synonym: 4981-83-3; Benzyl-PEG2-Tos; 2-(Benzyloxy)ethyl 4-methylbenzenesulfonate; Benzyl-PEG1-Tos; 2-(Benzyloxyethyl) p-toluenesulfonate

CAS Number: 4981-83-3
PubChem CID: 561375

Size

500 mg; 1 g; 2 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Benzyl-PEG2-Tos is a PEG linker featuring an acid-labile benzyl protecting group and a tosyl leaving group. The tosyl group serves as an effective leaving moiety in various chemical reactions. With its hydrophilic PEG linker, this compound demonstrates enhanced water solubility in aqueous solutions.

Molecular Weight

306.4

Molecular Formula

C₁₆H₁₈O₄S

Functional Group 1

Benzyl

Functional Group 2

Tos

Functional Group 3

None

Form

Liquid

Purity

98%

Identity

Confirmed by NMR.

Applications

Benzyl-PEG2-Tos is widely employed in organic synthesis as a versatile building block due to its acid-labile nature and the reactivity of the tosyl leaving group. It is commonly utilized in the preparation of peptide conjugates, prodrugs, and other pharmaceutical intermediates. The hydrophilic PEG linker contributes to the solubility of the compound in water-based systems, facilitating its use in aqueous reactions and formulations.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.