Biotin/Picolyl azide PEG reagent, Biotin-PEG4-picolyl azide, Purity 95%

Synonym: 2222687-71-8; Biotin-PEG4-picolyl azide; AKOS040743044; BP-22954

CAS Number: 2222687-71-8
PubChem CID: 102514780

Size

5 mg; 25 mg; 100 mg

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Biotin-PEG4-picolyl azide is a specialized biotinylation reagent designed for conjugation with alkyne-containing biomolecules. Featuring a picolyl azide moiety, this reagent facilitates efficient labeling via- Cu(I)-catalyzed Click Chemistry. The incorporation of a copper-chelating motif enhances reaction kinetics, enabling rapid and specific coupling with alkyne-functionalized targets. Compared to conventional biotin azide, the use of picolyl azide allows for significant reduction in the concentration of copper catalyst required for labeling while maintaining high efficiency.

Molecular Weight

622.7

Molecular Formula

C₂₇H₄₂N₈O₇S

Functional Group 1

Biotin

Functional Group 2

Picolyl azide

Functional Group 3

None

Form

Liquid/Solid (low melting point)

Purity

95%

Identity

Confirmed by NMR.

Applications

Biotin-PEG4-picolyl azide finds application in various bioconjugation and labeling experiments where precise and selective modification of biomolecules is required. Its compatibility with Cu(I)-catalyzed Click Chemistry makes it particularly suitable for site-specific biotinylation of proteins, nucleic acids, and other macromolecules containing alkyne groups. By offering improved reaction kinetics and requiring lower copper catalyst concentrations, this reagent enhances labeling efficiency while minimizing potential cytotoxic effects associated with excess copper. Its versatility and efficiency make it valuable in applications such as protein labeling, imaging, and affinity purification assays.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.