Biotin/TFP PEG reagent, TFP-PEG12-biotinidase resistant biotin, Purity 95%

Synonym: TFP-PEG12-biotinidase resistant biotin; GS-9358; TFP-dPEG(R)12-biotinidase resistant biotin

PubChem CID: 124203838

Size

100 mg

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TFP-PEG12-biotinidase features a biotin moiety and a TFP ester end group. The biotin group readily reacts with primary amino (-NH2) compounds, forming stable and irreversible amide bonds. Additionally, the hydrophilic PEG spacer arm enhances water solubility, ensuring compatibility with various biological applications. The TFP ester functionality provides versatility in conjugation reactions with primary amine groups and exhibits greater stability against hydrolysis compared to NHS ester reagents.

Molecular Weight

1,077.2

Molecular Formula

C₄₇H₇₆F₄N₄O₁₇S

Functional Group 1

Biotin

Functional Group 2

TFP

Functional Group 3

None

Reactive Group 1

Amine

Form

Reported

Purity

95%

Identity

Confirmed by NMR.

Applications

TFP-PEG12-biotinidase is ideal for site-specific biotinylation of proteins, peptides, and other biomolecules containing primary amine groups. The reaction between the biotin moiety and primary amines results in the formation of stable amide bonds, facilitating robust and irreversible conjugation. The hydrophilic PEG spacer arm enhances the solubility of the biotinylated molecule in aqueous environments, making it suitable for various biological assays, imaging studies, and diagnostic applications.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.