Description
N-(Boc-PEG3)-N-bis-(PEG3-amino-Tri-(propargyl-PEG2-ethoxymethyl)-methane) is a reagent grade crosslinker consisting of six propargyl groups and a t-Boc protected aminooxy group. The propargyl groups form triazole linkage with azide-bearing biomolecules or compounds via- copper-catalyzed click chemistry. The protected amine is deprotected under acidic conditions. The hydrophilic PEG spacer increases solubility in aqueous media.
Applications
N-(Boc-PEG3)-N-bis-(PEG3-amino-Tri-(propargyl-PEG2-ethoxymethyl)-methane) is useful in bioconjugation strategies where protecting groups are advantageous during synthesis. Once deprotected, the amines form stable conjugates with various biomolecules, suitable for drug delivery and imaging applications.