Description
DBCO-PEG4-Butyraldehyde is a PEG-based reagent designed for click chemistry applications, featuring a terminal butyraldehyde group. This functional group enables reactions with hydrazides to form stable hydrazone linkages or with alkoxyamines to form stable oxime bonds. The hydrophilic PEG spacer arm enhances water solubility and offers a flexible connection, reducing steric hindrance during ligation processes.
Applications
DBCO-PEG4-Butyraldehyde is utilized in various bioconjugation and chemical synthesis applications, particularly in the formation of stable linkages between biomolecules or synthetic compounds. Its reactivity with hydrazides and alkoxyamines facilitates the creation of robust conjugates with precise control over linker length and orientation. Additionally, the compatibility with copper-free click chemistry reactions broadens its utility in diverse research and development endeavors.