Carboxylic acid/NHS PEG reagent, Acid-PEG5-NHS ester, Purity 95%

Synonym: 1343476-41-4; Acid-PEG5-NHS ester; Acid-C₂-PEG4-C₂-NHS ester; COOH-PEG5-NHS; 19-((2,5-dioxopyrrolidin-1-yl)oxy)-19-oxo-4,7,10,13,16-pentaoxanonadecanoic acid

CAS Number: 1343476-41-4
PubChem CID: 77078184

Size

100 mg; 500 mg; 1 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Acid-PEG5-NHS ester is a PEG linker that features both a carboxylic acid and an NHS ester. The hydrophilic PEG spacer enhances solubility in aqueous solutions. The terminal carboxylic acid can react with primary amine groups when activated by agents such as EDC or HATU, resulting in stable amide bond formation. This NHS ester is suitable for labeling primary amines t-found in proteins, amine-modified oligonucleotides, and other molecules containing amino groups.

Molecular Weight

435.4

Molecular Formula

C₁₈H₂₉NO₁₁

Functional Group 1

Acid

Functional Group 2

Ester

Functional Group 3

NHS

Reactive Group 1

Amine

Form

Solid or viscous liquid

Purity

95%

Identity

Confirmed by NMR.

Applications

Acid-PEG5-NHS ester is often used in the modification of biomolecules and surfaces to introduce carboxylic acid functionalities. It can be employed in the conjugation of drugs or ligands to provide acidic groups for specific interactions or to modify the charge properties of biomaterials.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.