Carboxylic acid/NHS PEG reagent, N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester), Purity 98%

Synonym: 2353409-57-9; N-(amino-PEG3)-N-bis(PEG4-Boc); N-(amino-PEG3)-N-bis(PEG4-t-butyl ester); AKOS040743626; BP-24287

CAS Number: 2353409-57-9
PubChem CID: 137700739

Size

100 mg; 250 mg; 500 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester) is a PEG linker comprising an amino group flanked by two PEG chains with t-butyl ester functionalities. This compound readily reacts with activated NHS esters or carboxylic acids in the presence of coupling reagents like EDC or HATU. The t-butyl ester groups can be selectively deprotected under acidic conditions.

Molecular Weight

801.0

Molecular Formula

C₃₈H₇₆N₂O₁₅

Functional Group 1

Carboxylic acid

Functional Group 2

NHS

Functional Group 3

None

Reactive Group 1

NHS

Form

Liquid

Purity

98%

Solubility

Water, DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

N-(Amino-PEG3)-N-bis(PEG4-t-butyl ester) can be used in bioconjugation and chemical synthesis. Its amino group enables conjugation with various biomolecules or surfaces, facilitating the attachment of proteins, peptides, or other molecules of interest. The t-butyl ester groups provide protection during synthesis, allowing for controlled deprotection when needed to expose the amino functionalities. This linker is particularly useful in the synthesis of peptide conjugates, surface modifications, and drug delivery systems where controlled release or surface immobilization is desired.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.