DBCO PEG reagent, DBCO-amine, TFA salt, Purity 95%

Synonym: 2007915-94-6; Dbco-amine TFA; Dbco-amineTFA; DBCO-amine TFA salt

MDL: MFCD30471854
CAS Number: 2007915-94-6
PubChem CID: 124081201

Size

100 mg; 250 mg; 500 mg; 1 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

DBCO-amine TFA salt is a fundamental building block comprising a DBCO moiety and an amine group, conveniently presented as a trifluoroacetate (TFA) salt. This versatile reagent enables the facile derivatization of carboxyl groups or activated esters, such as the NHS ester, via- stable amide bond formation in the presence of activators like EDC or HATU. Renowned for its bioorthogonal reactivity, DBCO facilitates efficient and specific labeling through copper-free Click Chemistry reactions, making DBCO-amine TFA salt a valuable tool for various bioconjugation applications.

Molecular Weight

390.4

Molecular Formula

C₂₀H₁₇F₃N₂O₃

Functional Group 1

DBCO

Functional Group 2

None

Functional Group 3

None

Form

Solid

Purity

95%

Identity

Confirmed by NMR.

Applications

DBCO-amine TFA salt can be used in bioconjugation studies and the synthesis of functionalized biomolecules. Its amine functionality enables conjugation with carboxyl-containing molecules or activated esters, allowing for the modification of peptides, proteins, nucleic acids, and other biomolecules. By utilizing the bioorthogonal reactivity of DBCO, DBCO-amine TFA salt enables the selective labeling of biomolecules with azide-bearing compounds under mild conditions, without the need for copper catalysts.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.