Description
DBCO-PEG13-DBCO is a bifunctional PEG linker featuring two terminal DBCO groups, designed for efficient bioconjugation via- copper-free Click Chemistry. With its long-chain structure, this reagent offers extended reach and flexibility, facilitating the conjugation of DBCO-functionalized molecules with azide-bearing compounds or biomolecules without the need for a copper catalyst. The hydrophilic PEG spacer arm not only enhances water solubility but also improves membrane permeability, making it suitable for various applications in chemical biology, diagnostics, and drug delivery.
Applications
DBCO-PEG13-DBCO finds widespread utility in bioconjugation applications where the formation of stable triazole linkages through copper-free Click Chemistry is desired. Its dual DBCO functionality enables the simultaneous labeling or functionalization of multiple sites on biomolecules or surfaces, enhancing versatility in molecular engineering and assembly.