Properties
Description
DBCO-PEG4-acid is a reagent grade analog of DBCO-Acid featuring a PEG linker and a DBCO group, designed for copper-free Click Chemistry reactions due to its strain-promoted high energy. The hydrophilic PEG chain increases water solubility.
Molecular Formula
C30H36N2O8
Form
Solid/liquid (low melting point)
Solubility
DMSO, DCM, DMF
Identity
Confirmed by NMR.
Applications
DBCO-PEG4-acid is used in bioconjugation and molecular biology research, facilitating efficient copper-free Click Chemistry reactions. Its terminal carboxylic acid can react with primary amine groups in the presence of activators like EDC or HATU to form stable amide bonds, making it ideal for modifying biomolecules and studying protein interactions.