DBCO/Gly PEG reagent, Gly-Gly-Gly-PEG4-DBCO, Purity 98%

Synonym: 2353409-80-8; Gly-Gly-Gly-PEG4-DBCO; AKOS040743345; BP-24191; MS-31151

CAS Number: 2353409-80-8
PubChem CID: 137334056

Size

10 mg; 25 mg; 50 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Gly-Gly-Gly-PEG4-DBCO is a cleavable PEG linker designed for the synthesis of antibody-drug conjugates (ADCs). The linker consists of three glycine residues followed by a PEG4 spacer and a terminal DBCO moiety.

Molecular Weight

694.8

Molecular Formula

C₃₅H₄₆N₆O₉

Functional Group 1

DBCO

Functional Group 2

Gly

Functional Group 3

None

Form

Liquid/Solid (low melting point)

Purity

98%

Solubility

Water, DMSO, DCM, DMF, Methanol

Identity

Confirmed by NMR.

Applications

Gly-Gly-Gly-PEG4-DBCO is utilized in the construction of ADCs, where it serves to connect cytotoxic drugs or payloads to antibodies via- site-specific conjugation chemistry. The cleavable nature of the linker enables controlled release of the payload within target cells, thereby enhancing the efficacy of the therapeutic agent while minimizing off-target effects. Gly-Gly-Gly-PEG4-DBCO offers precise control over drug loading and release kinetics, making it valuable for the development of novel antibody-based therapeutics with improved selectivity and potency.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.