DBCO/Maleimide PEG reagent, DBCO-PEG6-Maleimide, Purity 95%

Synonym: DBCO-NHCO-PEG6-maleimide; DBCO-NH-PEG6-Maleimide; DBCO-PEG6-Maleimide; DBCO-NH-PEG6-Mal; AKOS040743179

PubChem CID: 118988589

Size

25 mg; 50 mg; 100 mg; 250 mg

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

DBCO-PEG6-Maleimide is a PEG linker featuring a DBCO moiety and a terminal primary maleimide group. This bifunctional reagent serves as a versatile tool for bioconjugation chemistry, facilitating the conjugation of biomolecules with thiol-containing compounds. The maleimide group readily reacts with thiol groups to form stable covalent bonds, enabling the site-specific modification of biomolecules with various functionalities.

Molecular Weight

762.9

Molecular Formula

C₄₀H₅₀N₄O₁₁

Functional Group 1

DBCO

Functional Group 2

Maleimide

Functional Group 3

None

Reactive Group 1

Thiol

Form

Liquid

Purity

95%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

DBCO-PEG6-Maleimide finds widespread application in bioconjugation studies, particularly in the field of protein labeling and modification. By reacting with thiol groups on proteins, peptides, or other biomolecules, the maleimide functionality allows for the introduction of DBCO moieties onto specific sites of interest. This enables subsequent conjugation reactions with azide-functionalized molecules via- copper-free Click Chemistry, providing a bioorthogonal and chemoselective approach for biomolecule functionalization.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.