Description
DBCO-NHCO-PEG4-NHS ester is a reagent grade PEG linker containing an NHS ester that reacts specifically and efficiently with primary amines at neutral or slightly basic conditions to form a covalent bond. The hydrophilic PEG spacer arm improves water solubility and provides a long, flexible connection that minimizes steric hindrance.
Applications
DBCO-NHCO-PEG4-NHS ester is used in bioconjugation and molecular biology research, facilitating efficient copper-free Click Chemistry reactions. It is ideal for modifying primary amines, enhancing water solubility, and reducing steric hindrance in protein interactions and surface modifications.