DBCO/NHS PEG reagent, DBCO-PEG5-NHS ester, Purity 98%

Synonym: 2144395-59-3; DBCO-PEG5-NHS ester; 4,7,10,13,16-Pentaoxa-19-azatricosanoic acid, 23-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-20,23-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester; Adibo-peg4-nhs ester

MDL: MFCD22380747
CAS Number: 2144395-59-3
PubChem CID: 134159305

Size

25 mg; 100 mg; 250 mg; 500 mg

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

DBCO-PEG5-NHS ester is a PEG linker incorporating both DBCO and NHS ester functionalities. The NHS ester group enables specific and efficient reactions with primary amines, such as those found in lysine residues or aminosilane-coated surfaces, under neutral or slightly basic conditions, forming stable covalent bonds. The inclusion of a PEG5 spacer enhances the water solubility of the compound, facilitating its application in aqueous media for various bioconjugation and labeling experiments.

Molecular Weight

693.8

Molecular Formula

C₃₆H₄₃N₃O₁₁

Functional Group 1

DBCO

Functional Group 2

NHS

Functional Group 3

None

Form

Semi-Solid

Purity

98%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

DBCO-PEG5-NHS ester is widely employed in bioconjugation and chemical modification studies for the labeling and functionalization of amine-containing molecules, including proteins, peptides, and antibodies. Its NHS ester moiety selectively reacts with primary amines, allowing for the site-specific attachment of the linker to target biomolecules.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.