Fmoc-protected Amine/NHS PEG reagent, Fmoc-PEG12-NHS ester, Purity 95%

Synonym: 2227246-92-4; 488085-18-3; Fmoc-PEG12-NHS ester; FmocNH-PEG12-NHS ester; Fmoc-N-amido-PEG12-NHS ester

CAS Number: 2227246-92-4
PubChem CID: 11535302

Size

250 mg; 500 mg; 1 g; 2 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Fmoc-PEG12-NHS ester functions as a PEG linker incorporating an Fmoc-protected amino group along with an NHS ester functionality. Its hydrophilic PEG spacer improves solubility when placed into aqueous media. The Fmoc protecting group can be removed under basic conditions to yield free aminogroups suitable for further conjugation reactions involving primary amines t-from proteins or modified oligonucleotides.

Molecular Weight

937.1

Molecular Formula

C₄₆H₆₈N₂O₁₈

Functional Group 1

Ester

Functional Group 2

Fmoc

Functional Group 3

NHS

Reactive Group 1

Amine

Form

Solid or viscous liquid

Purity

95%

Solubility

DCM

Identity

Confirmed by NMR.

Applications

In peptide synthesis, it is used to add long PEG chains and Fmoc protection groups. The PEG moiety improves the solubility and pharmacokinetic properties of the peptides, making them more suitable for therapeutic use. It can also be used in the modification of proteins to create conjugates for drug delivery or for improving the stability and functionality of enzymes.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.