Hydroxyl/t-Butyl ester PEG reagent, Hydroxy-PEG4-t-butyl ester, Purity 98%

Synonym: 518044-32-1; Tert-BUTYL 1-HYDROXY-3,6,9,12-TETRAOXAPENTADECAN-15-OATE; Hydroxy-PEG4-t-butyl ester; Hydroxy-PEG4-t-butly ester; HO-PEG4-CH₂CH₂COOtBu

MDL: MFCD11041117
CAS Number: 518044-32-1
PubChem CID: 11174684

Size

1 g; 5 g; 10 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Hydroxy-PEG4-t-butyl ester is a PEG linker featuring a terminal hydroxyl group and a t-butyl-protected carboxyl group. The PEG4 spacer enhances hydrophilicity and solubility in aqueous environments. The hydroxyl group serves as a versatile site for further derivatization, while the t-butyl ester provides acid-labile protection for controlled carboxylic acid activation.

Molecular Weight

322.4

Molecular Formula

C₁₅H₃₀O₇

Functional Group 1

Hydroxyl

Functional Group 2

t-Butyl ester

Reactive Group 1

Acid

Reactive Group 2

Nucleophile

Form

Liquid

Purity

98%

Solubility

Water, DCM

Identity

Confirmed by NMR.

Applications

Hydroxy-PEG4-t-butyl ester is widely used in bioconjugation, drug delivery, and polymer synthesis. Its hydroxyl group supports versatile functionalization, and the t-butyl ester allows precise activation of the carboxyl group under acidic conditions, making it ideal for creating hydrophilic linkers and functional materials in pharmaceutical and biomedical research.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.