Hydroxyl/t-Butyl protected carboxyl PEG reagent, Hydroxy-PEG2-CH₂CO₂tBu, Purity 95%

Synonym: 149299-82-1; Hydroxy-PEG2-CH₂CO₂tBu; Tert-Butyl 2-(2-(2-hydroxyethoxy)ethoxy)acetate; Hydroxy-PEG2-t-Butyl acetate; HO-PEG2-CH₂COOtBu

MDL: MFCD25959245
CAS Number: 149299-82-1
PubChem CID: 19780618

Size

500 mg; 1 g; 5 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Hydroxy-PEG2-CH₂CO₂tBu is a PEG linker featuring a terminal hydroxyl group and a t-butyl-protected carboxyl group. The PEG2 spacer enhances solubility in aqueous environments, while the hydroxyl group allows versatile functionalization. The t-butyl group provides acid-labile protection for controlled carboxyl activation.

Molecular Weight

220.3

Molecular Formula

C₁₀H₂₀O₅

Functional Group 1

Hydroxyl

Functional Group 2

t-Butyl protected carboxyl

Reactive Group 1

Acid

Reactive Group 2

Nucleophile

Form

Liquid

Purity

95%

Solubility

Water, DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

Hydroxy-PEG2-CH₂CO₂tBu is used in bioconjugation, drug delivery, and material synthesis. The hydroxyl group supports further derivatization, while the t-butyl ester ensures precise activation of the carboxyl group under acidic conditions, making it ideal for creating hydrophilic linkers and functional materials.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.

Hydroxyl/t-Butyl protected carboxyl PEG reagent, Hydroxy-PEG2-CH2CO2tBu, Purity 95%

Hydroxyl/t-Butyl protected carboxyl PEG reagent, Hydroxy-PEG2-CH₂CO₂tBu, Purity 95%