Hydroxyl/t-Butyl protected carboxyl PEG reagent, Hydroxy-PEG4-CH₂CO₂tBu, Purity 95%

Synonym: 169751-72-8; HO-PEG4-CH₂COOtBu; Hydroxy-PEG4-CH₂-Boc; Hydroxy-PEG4-CH₂CO₂tBu; HO-PEG4-CH₂CO₂t-Bu

MDL: MFCD27635170
CAS Number: 169751-72-8
PubChem CID: 57747741

Size

500 mg; 1 g; 5 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Hydroxy-PEG4-CH₂CO₂tBu is a PEG-based linker featuring a terminal hydroxyl group and a t-butyl-protected carboxyl group. The hydroxyl group serves as a versatile reactive site for chemical modifications, while the t-butyl group provides acid-labile protection to the carboxyl functionality, allowing controlled deprotection. The PEG4 spacer enhances hydrophilicity and solubility in aqueous environments, facilitating its use in various applications.

Molecular Weight

308.4

Molecular Formula

C₁₄H₂₈O₇

Functional Group 1

Hydroxyl

Functional Group 2

t-Butyl protected carboxyl

Reactive Group 1

Acid

Reactive Group 2

Nucleophile

Form

Liquid

Purity

95%

Solubility

Water, DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

Hydroxy-PEG4-CH₂CO₂tBu is widely utilized in bioconjugation, drug delivery, and advanced material synthesis. Its hydroxyl group supports further functionalization for creating hydrophilic linkers, while the t-butyl ester ensures targeted activation of the carboxyl group under acidic conditions. This compound is ideal for developing water-soluble conjugates and functional biomaterials in pharmaceutical and biomedical research.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.

Hydroxyl/t-Butyl protected carboxyl PEG reagent, Hydroxy-PEG4-CH2CO2tBu, Purity 95%

Hydroxyl/t-Butyl protected carboxyl PEG reagent, Hydroxy-PEG4-CH₂CO₂tBu, Purity 95%