Iodoacetamide/t-Butyl ester PEG reagent, Iodoacetamido-PEG3-t-butyl ester, Purity 95%

Synonym: Iodoacetamido-PEG3-t-butyl ester

PubChem CID: 167312685

Size

50 mg; 100 mg; 250 mg

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Iodoacetamido-PEG3-t-butyl ester is a bifunctional PEG linker featuring an iodoacetamide group and a t-butyl ester-protected carboxyl group. The iodoacetamide acts as a strong alkylating agent, allowing for covalent binding with thiol groups, while the t-butyl ester provides acid-labile protection, facilitating controlled deprotection during synthesis.

Molecular Weight

445.3

Molecular Formula

C₁₅H₂₈INO₆

Functional Group 1

Iodoacetamide

Functional Group 2

t-Butyl ester

Reactive Group 1

Acid

Reactive Group 2

Thiol

Form

Solid

Purity

95%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

Iodoacetamido-PEG3-t-butyl ester is utilized in protein modification, bioconjugation, and targeted drug delivery. It enables specific thiol labeling of cysteine residues, while the acid-cleavable t-butyl ester allows for precise release of the reactive carboxylic acid, making it ideal for creating stable, functionalized biomolecule conjugates in biomedical research.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.