t-Butyl ester PEG reagent, N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester), Purity 98%

Synonym: 2112737-19-4; N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester); N-(Aminooxy-PEG3)-N-bis(PEG4-Boc); N-(AMINOOXY-PEG3)-N-BIS(PEG4-t-BUTYLESTER); DTXSID601100259

CAS Number: 2112737-19-4
PubChem CID: 126961966

Size

100 mg; 250 mg; 500 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester) is a bifunctional PEG linker featuring aminooxy groups and t-butyl ester moieties. The aminooxy groups can selectively react with aldehydes to form stable oxime bonds or with ketones to yield hydroxylamine linkages upon reduction. The t-butyl ester groups are susceptible to hydrolysis under acidic conditions, facilitating further modification. The hydrophilic PEG linkers enhance the water solubility and biocompatibility of the compound.

Molecular Weight

817.0

Molecular Formula

C₃₈H₇₆N₂O₁₆

Functional Group 1

t-Butyl ester

Functional Group 2

None

Functional Group 3

None

Reactive Group 1

Aldehyde

Form

Liquid

Purity

98%

Identity

Confirmed by NMR.

Applications

N-(Aminooxy-PEG3)-N-bis(PEG4-t-butyl ester) can be used in bioconjugation chemistry, particularly in the labeling and modification of biomolecules. Its ability to selectively react with aldehydes and ketones makes it valuable for site-specific conjugation and immobilization of proteins, peptides, and carbohydrates. The resulting oxime or hydroxylamine linkages offer stability and versatility in various biological and biomedical applications, including drug delivery systems, diagnostics, and biomaterials engineering. Additionally, the hydrolysis of t-butyl ester groups enables controlled release of payloads or attachment of functional groups for downstream applications.

Storage

Store at -20°C

For Research Use Only. Not For Clinical Use.