t-Butyl ester PEG reagent, tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate, Purity 95%

Synonym: 1950635-36-5; tert-butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate; Thalidomide-4-O-CH₂-COO(t-Bu); ACETIC ACID, 2-[[2-(2,6-DIOXO-3-PIPERIDINYL)-2,3-DIHYDRO-1,3-DIOXO-1H-ISOINDOL-4-YL]OXY]-, 1,1-DIMETHYLETHYL ESTER; SCHEMBL17839798

CAS Number: 1950635-36-5
PubChem CID: 121411060

Size

250 mg; 500 mg; 1 g; 5 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate is a reagent grade PROTAC linker featuring a thalidomide analog, a hydrophilic PEG spacer, and a t-butyl ester.

Molecular Weight

388.4

Molecular Formula

C₁₉H₂₀N₂O₇

Functional Group 1

t-Butyl ester

Functional Group 2

None

Functional Group 3

None

Reactive Group 1

Acid

Form

Solid

Purity

95%

Identity

Confirmed by NMR.

Applications

tert-Butyl 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetate is utilized in synthesizing targeted drug conjugates, and bioconjugation research. Thalidomide recruits E3 Ligase for the ubiquitination and subsequent destruction of a given protein.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.