LC-2, Purity 95%

Synonym: LC-2; 2502156-03-6; (2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; PROTAC KRASG12C Degrader-LC-2; (2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m

CAS Number: 2502156-03-6
PubChem CID: 154727765

Size

1 mg; 5 mg; 10 mg; 25 mg

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LC-2 is a reagent grade von Hippel-Lindau-based PROTAC which degrades endogenous KRAS G12C.

Molecular Weight

1132.8

Molecular Formula

C₅₉H₇₁ClFN₁₁O₇S

Form

Solid

Purity

95%

Identity

Confirmed by NMR.

Applications

LC-2 is used to covalently bind KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterozygous KRAS G12C cell lines.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.