Maleimide PEG reagent, Bis-Mal-PEG6, Purity 98%

Synonym: 2458811-07-7; Bis-Mal-PEG6; Mal-NH-PEG6-NH-Mal

CAS Number: 2458811-07-7
PubChem CID: 77078212

Size

500 mg; 1 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Bis-Mal-PEG6 is a PEG linker containing two maleimide groups. The maleimide groups are highly reactive with thiol groups and form covalent bonds, making it ideal for linking thiol-containing biomolecules. The hydrophilic PEG spacer (6 ethylene glycol units) enhances the solubility of this compound in aqueous media, improving its stability and making it suitable for various research applications. The presence of two maleimide groups allows for the efficient conjugation of biomolecules, providing versatile options for crosslinking.

Molecular Weight

626.7

Molecular Formula

C₂₈H₄₂N₄O₁₂

Functional Group 1

Maleimide

Reactive Group 1

Thiol

Form

Liquid/Solid (low melting point)

Purity

98%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

Bis-Mal-PEG6 is widely used in the development of bioconjugates, particularly for crosslinking proteins, peptides, antibodies, and other thiol-containing biomolecules. It is valuable in applications such as the synthesis of antibody-drug conjugates (ADCs), targeted drug delivery systems, and the construction of multi-functional biomolecular complexes. The dual maleimide functionality ensures robust and efficient conjugation for a variety of research-based applications.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.