Maleimide/NHS ester PEG reagent, Mal-amido-PEG3-NHS, Purity 95%

Synonym: 2055353-77-8; MAL-Tri-EG-Osu; Mal-amido-PEG3NHSester; 2,5-Dioxopyrrolidin-1-yl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3-oxo-7,10,13-trioxa-4-azahexadecan-16-oate

CAS Number: 2055353-77-8
PubChem CID: 129896954

Size

250 mg; 500 mg; 1 g; 5 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Mal-amido-PEG3-NHS is a PEG linker containing a maleimide group and an NHS ester. The maleimide group reacts with thiol groups to form stable covalent bonds, enabling the attachment of thiol-containing biomolecules. The NHS ester can react with primary amines to form amide bonds, making this linker versatile for conjugation reactions. The hydrophilic PEG spacer enhances the water solubility of compounds, making it particularly suitable for aqueous-based applications in research and development.

Molecular Weight

469.5

Molecular Formula

C₂₀H₂₇N₃O₁₀

Functional Group 1

Maleimide

Functional Group 2

NHS ester

Reactive Group 1

Amine

Reactive Group 2

Thiol

Form

Liquid

Purity

95%

Identity

Confirmed by NMR.

Applications

Mal-amido-PEG3-NHS is widely used in bioconjugation applications, including protein labeling, oligonucleotide conjugation, and surface functionalization. It is particularly useful in the synthesis of antibody-drug conjugates (ADCs), where it enables stable attachment to biomolecules with thiol or amine groups for research purposes.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.