Maleimide/TFP PEG reagent, Mal-amido-PEG4-TFP ester, Purity 95%

Synonym: 1807540-84-6; Mal-NH-PEG4-TFP; (2,3,5,6-Tetrafluorophenyl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate; 2,3,5,6-Tetrafluorophenyl 1-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]-3,6,9,12-tetraoxapentadecan-15-oate

CAS Number: 1807540-84-6
PubChem CID: 91757746

Size

250 mg; 1 g; 5 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Mal-amido-PEG4-TFP ester is a PEG linker with a maleimide group and a TFP ester at each terminus. The maleimide group reacts selectively with thiol groups at pH 6.5–7.5, while the TFP ester efficiently couples with primary amines and offers enhanced stability against hydrolysis compared to NHS esters. The PEG4 spacer improves solubility and hydrophilicity in aqueous environments.

Molecular Weight

564.5

Molecular Formula

C₂₄H₂₈F₄N₂O₉

Functional Group 1

Maleimide

Functional Group 2

TFP

Reactive Group 1

Amine

Reactive Group 2

Thiol

Form

Liquid

Purity

95%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

Mal-amido-PEG4-TFP ester is employed in research for creating multifunctional bioconjugates, studying thiol-specific reactions, and designing amine-reactive linkers. Its dual reactivity enables the synthesis of thiol-amine crosslinked materials, making it ideal for protein labeling, surface modifications, and the development of advanced biomolecular scaffolds.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.