NHS PEG reagent, Bis-sulfone NHS ester, Purity 95%

Synonym: 899452-51-8; Bis-sulfone NHS ester; 2,5-Dioxopyrrolidin-1-yl 4-(3-tosyl-2-(tosylmethyl)propanoyl)benzoate; 4-[2,2-bis[(p-tolylsulfonyl)-methyl]acetyl]benzoic acid N-succinimidyl ester

CAS Number: 899452-51-8
PubChem CID: 6420087

Size

100 mg; 500 mg; 1 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Bis-sulfone NHS ester serves as a bis-alkylating labeling agent that specifically targets cysteine sulfur atoms from native disulfides. These reagents facilitate bis-alkylation, allowing for conjugation of thiols derived from two cysteine residues within a reduced native disulfide bond, such as those found in interchain disulfides of antibodies. This reaction leads to covalent rebridging of the disulfide bond through a three-carbon bridge while preserving the structural integrity of the protein.

Molecular Weight

597.7

Molecular Formula

C₂₉H₂₇NO₉S₂

Functional Group 1

Ester

Functional Group 2

NHS

Functional Group 3

Sulfonyl

Reactive Group 1

Amine

Form

Solid or viscous liquid

Purity

95%

Identity

Confirmed by NMR.

Applications

It can be used in bioconjugation reactions and the modification of biomolecules.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.