NHS PEG reagent, t-Butoxycarbonyl-PEG1-NHS ester, Purity 98%

Synonym: 2228857-37-0; t -Butoxycarbonyl-PEG1-NHS ester; t-butyl 3-(3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropoxy)propanoate

CAS Number: 2228857-37-0
PubChem CID: 134159749

Size

100 mg; 250 mg; 500 mg

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

t-Butoxycarbonyl-PEG1-NHS ester features a t-Boc protecting group along with an NHS ester moiety. The t-Boc group can be eliminated under acidic conditions. Additionally, the hydrophilic PEG spacer enhances solubility in aqueous environments. This NHS ester reacts selectively and efficiently with primary amines (such as those found in lysine side chains or on aminosilane-coated surfaces) at neutral or slightly basic pH levels to create covalent bonds.

Molecular Weight

315.3

Molecular Formula

C₁₄H₂₁NO₇

Functional Group 1

Ester

Functional Group 2

NHS

Functional Group 3

None

Reactive Group 1

Amine

Form

Solid or viscous liquid

Purity

98%

Identity

Confirmed by NMR.

Applications

This compound is often used in peptide synthesis and bioconjugation. It serves as a linker to attach PEG (polyethylene glycol) chains to biomolecules, facilitating solubility and bioavailability.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.