NHS PEG reagent, t-Butoxycarbonyl-PEG2-NHS ester, Purity 95%

Synonym: tert-butyl 3-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]propanoate

CAS Number: 2411681-93-9

Size

100 mg; 250 mg; 500 mg; 1 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

t-Butoxycarbonyl-PEG2-NHS ester contains both a t-Boc protecting group and an NHS ester functionality. The t-butyl group can be deprotected under acidic conditions, allowing the NHS ester to react specifically and efficiently with primary amines such as those on lysine side chains or surfaces coated with aminosilane at neutral or slightly basic pH levels to form covalent bonds. Its hydrophilic PEG linker increases the compound's water solubility when placed into aqueous media.

Molecular Weight

359.4

Molecular Formula

C₁₆H₂₅NO₈

Functional Group 1

Ester

Functional Group 2

NHS

Functional Group 3

None

Reactive Group 1

Amine

Form

Solid or viscous liquid

Purity

95%

Identity

Confirmed by NMR.

Applications

t-Butoxycarbonyl-PEG2-NHS ester is often utilized in organic synthesis and medicinal chemistry. In the synthesis of small molecule drugs, it can be used to introduce a PEG spacer and a protecting group simultaneously. The PEG moiety can enhance the solubility and bioavailability of the resulting compounds.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.