NHS PEG reagent, m-PEG5-NHS ester, Purity 98%

Synonym: 874208-94-3; m-PEG5-NHS ester; 2,5-Dioxopyrrolidin-1-yl 2,5,8,11,14-pentaoxaheptadecan-17-oate; mPEG4-CH₂CH₂COONHS ester; (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]propanoate

CAS Number: 874208-94-3
PubChem CID: 57890907

Size

100 mg; 1 g; 5 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

m-PEG5-NHS ester is a PEG linker that includes an NHS ester. This NHS ester can be utilized for labeling primary amines t-present in proteins, amine-modified oligonucleotides, and other molecules containing amino groups. The hydrophilic nature of the PEG spacer enhances solubility in aqueous solutions.

Molecular Weight

377.4

Molecular Formula

C₁₆H₂₇NO₉

Functional Group 1

Ester

Functional Group 2

NHS

Functional Group 3

None

Reactive Group 1

Amine

Form

Solid or viscous liquid

Purity

98%

Solubility

DMSO, DCM, DMF

Identity

Confirmed by NMR.

Applications

m-PEG5-NHS ester is commonly used in the field of biomolecular modification. It can be employed to PEGylate proteins and peptides, enhancing their stability, solubility, and reducing their immunogenicity. In drug delivery systems, it helps increase the circulation time of drugs. It is also utilized in the surface modification of nanoparticles to improve their biocompatibility and biodistribution.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.