NHS PEG reagent, Mono-sulfone NHS ester

Synonym: Monosulfone N-hydroxysuccinimide ester; Mono-sulfonyl NHS ester; Sulfonic NHS ester; Monosulfone NHS

Size

1 g; 5 g

Price

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Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Mono-sulfone acts as a thiol-specific labeling agent that undergoes alkylation to form thioether bonds between proteins and mono-sulfone activated reagents. Once conjugated to a protein or peptide, this mono-sulfone reagent minimizes the risk of exchange reactions leading to deconjugation when treated with mild reducing agents, similar to processes used in reductive amination conjugations.

Molecular Weight

429.5

Molecular Formula

C₂₁H₁₉NO₇S

Functional Group 1

Ester

Functional Group 2

NHS

Functional Group 3

Sulfonyl

Reactive Group 1

Amine

Form

Solid or viscous liquid

Solubility

DMSO, DMF, DCM, THF, Chloroform

Identity

Confirmed by NMR.

Applications

Mono-sulfone NHS ester is commonly employed in chemical reactions for the conjugation of various molecules, especially in bioconjugation processes.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.