NHS/Maleimide PEG reagent, Mal-PEG1-NHS ester, Purity 98%

Synonym: 1807518-72-4; Mal-PEG1-NHS ester; 2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate; Mal-PEG1-SPA; 2,5-dioxopyrrolidin-1-yl 3-[2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]propanoate

CAS Number: 1807518-72-4
PubChem CID: 59992617

Size

100 mg; 250 mg; 1 g; 5 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Mal-PEG1-NHS ester acts as a PEG linker characterized by its maleimide functionality alongside an NHS ester moiety. The presence of its hydrophilic PEG spacer enhances solubility in aqueous solutions as well. This NHS ester enables labeling of primary amines t-located within proteins or other related substances containing amino groups while allowing the maleimide component to react with thiol groups forming covalent bonds that facilitate connections between biomolecules with thiols.

Molecular Weight

310.3

Molecular Formula

C₁₃H₁₄N₂O₇

Functional Group 1

NHS

Functional Group 2

Ester

Functional Group 3

Maleimide

Reactive Group 1

Thiol

Reactive Group 2

Amine

Form

Solid or viscous liquid

Purity

98%

Solubility

DCM

Identity

Confirmed by NMR.

Applications

Maleimide functionalized PEG is used for the conjugation to thiol groups in proteins, antibodies, or peptides. It is useful in creating antibody-drug conjugates (ADCs) and for various biotechnology applications where specific coupling to thiols is required.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.