Propargyl/t-Butyl ester PEG reagent, Propargyl-PEG4-sulfone-PEG4-t-butyl ester, Purity 98%

Synonym: 2055024-43-4; Propargyl-PEG4-sulfone-PEG4-t-butyl ester; Propargyl-PEG4-sulfone-PEG4-Boc; PROPARGYL-PEG4-SULFONE-PEG4-T-BUTYLESTER; AKOS040743809

CAS Number: 2055024-43-4
PubChem CID: 123132151

Size

100 mg; 250 mg; 500 mg; 1 g

Price

Inquiry

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Propargyl-PEG4-sulfone-PEG4-t-butyl ester is a reagent grade PEG linker with a t-butyl protected carboxyl group acid and propargyl group, designed for copper-catalyzed azide-alkyne click chemistry reactions. Under standard acid/amine or acid/hydroxyl coupling conditions, the t-butyl-protected carboxyl group (COOH) prevents self-coupling or polymerization. The PEG spacer increases water solubility.

Molecular Weight

584.7

Molecular Formula

C₂₆H₄₈O₁₂S

Functional Group 1

Propargyl

Functional Group 2

t-Butyl ester

Functional Group 3

None

Reactive Group 1

Azide

Form

Liquid

Purity

98%

Identity

Confirmed by NMR.

Applications

Propargyl-PEG4-sulfone-PEG4-t-butyl ester is used in molecular biology and bioconjugation research, promoting efficient copper-catalyzed azide-alkyne click chemistry to yield stable triazole linkages. Its bioorthogonal reactivity, combined with the advantageous properties of PEG makes it a valuable tool in drug delivery systems, synthetic chemistry, and materials development.

Storage

Store at -20°C.

For Research Use Only. Not For Clinical Use.